Procurement of nCounter Pro Analysis System and Support Services

Statement of Work Procurement of nCounter Pro Analysis System 1.0 Purpose Requesting instrument upgrade to nCounter Pro Analysis System, plus reagent and consumables, and technical service and support contract for existing instrumentation to include GeoMx System (serial # 2106G0279). This instrument will enable the development of in-house robust tumor testing for actionable treatment decisions. This platform combined with the Digital Spatial profiler will provide in-house actionable tumor information to guide therapy management and potential clinical trial enrollment for our Veterans. 2.0 Scope The Contractor will provide instrument and related components including printers and power supplies, all reagents, supplies, and consumables, technical and field support, service, and training for testing. The Contractor shall: Deliver, install, and set up the instrument and components. Provide test validation guidance. Provide technical support and guidance. Provide reagents, consumables, and supplies as requested by VANTHCS staff. Provide instrument repairs and scheduled preventive maintenance for the instrument and system components. Provide operator training. 3.0 Location The Nanostring Instrumentation is in the Molecular Department, Pathology & Laboratory Medicine Service (P&LMS) at VA North Texas Health Care System (VANTHCS), 4500 S. Lancaster Rd, Dallas, TX 75216. 4.0 Performance Product testing

requirements include the following: Single tube multiplexing Up to 800 genes or regions, quantitative analysis Ease-of-use Fully automated, intuitive user interface Flexible sample

requirements small samples from a variety of sources, including FFPE Comprehensive Content Off-the-shelf gene expression panels for human, mouse, non-human primate, and canine available for a variety of research areas Flexible Experimental Design Tailor assay content to meet individual project needs by adding up to 55 user-defined targets with Panel Plus Expandable Throughput increase sample capacity by adding a second Prep Station and multiplex up to 96 samples in one cartridge with PlexSet reagent. Maintenance agreement include the following: Ensuring equipment components perform within designated parameters to ensure proper performance according to manufacturer s specifications. Repairs and Support. Technical Support: Support Personnel will be available by telephone during normal business hours Monday through Friday 8:00am-4:30pm local time, excluding holidays. On-site Repairs: With respect to any technical support issue that the contractor determines to require on-site support at VANTHCS, contractor will dispatch one or more Service Personnel to VANTHCS, normally within 48 business hours after the complaint has been logged by Customer Support. Contractor supplies unlimited service visits Monday through Friday 8:00am 5:00pm local time, excluding federal holidays. For the delivery of repair parts or materials, the contractor shall provide all parts and materials at no additional cost the government. Contractor shall remove all parts, equipment or materials replaced or upgraded by the contractor due to and not limited to repairs, replacements, recall, and upgrades without any cost to the government. Safety Contractor shall immediately notify the service of any changes in reagent composition, procedure modification, recall notification or any changes that will affect the performance of the test or procedure according to FDA regulations. Test Performance All tests, procedures, and equipment must perform at manufacturer specifications; deviations from the performance specifications shall be corrected by the contractor. 5.0

Period of Performance Service Agreement for the Bruker - Nanostring Instrumentation will be established after delivery and installation. 6.0

Deliverables/Supplies This order is for the procurement of instrumentation, service, technical support, and maintenance of the Nanostring Instrumentation. The contractor shall provide all necessary warranted repair parts and the travel and labor to install parts. The contractor shall deliver all equipment necessary for instrument maintenance at no additional cost. The contractor shall provide labor and preventive maintenance kits for preventive maintenance visits. The contractor shall perform test verification according to manufacturer specification and CAP

requirements. The contractor shall deliver all invoices for review according to the established contract at the end of each billing cycle. All items not contracted shall be specifically detailed on the invoice including description, quantity acquired, and government cost. Any equipment modifications shall be immediately disclosed by the contractor electronically as well as by postal mail with supporting documentation of the change and detailed guidance against implementation within twenty -four hours of its application. Additional charges incurred by the government to provide the continuity of contracted tests to patients and not limited to outsourcing, transportation and or any other additional cost shall be covered by the contractor at no additional charge to the government. NARA Records Management Language for Contracts (May