Whole Exome Analysis of Clinical Center Patients
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The Department of Health and Human Services is procuring whole exome analysis for the NIAAA Clinical Center patient cohort. The project requires the use of the AmpliSeq Exome enrichment system and ION sequencing platform to maintain analytical integrity across samples. The goal is to identify underlying causes of alcohol related disorders through high throughput genome-wide analysis.
Scope & Requirements
Perform whole exome genome-wide analysis on NIAAA Clinical Center patients using the AmpliSeq Exome enrichment system and ION sequencing platform.
Deliverables
- Whole exome analysis data
Contract Details
- Contract Typei
- FFP
- Estimated Value
- est. $50K – $150KSimilar contracts award $15K to $88K (median $25K, 1,242 awards)Above typical range
- Incumbent Contractor
- LIFETECHNOLOGIES INC
- NAICS Codes
- Place of Performance
- BETHESDA, MD, USA
Agency & Contact
Contracting Organization
- Agency
- HEALTH AND HUMAN SERVICES, DEPARTMENT OF
- Sub-Agency
- NATIONAL INSTITUTES OF HEALTH - DRUGS AND BIOLOGICALS
Point of Contact
Key Dates
Description
The NIAAA Clinical Center patient cohort has been analyzed patients for sequence variant differences, and changes in response to treatment over the course of many years as part of an effort to identify underlying causes of alcohol related disorders. Analysis has previously been performed on over 2000 patients using the AmpliSeq Exome enrichment system and sequenced on the ION sequencing platform because it provides the capability of cost-effective high throughput whole-exome genome-wide analysis. The use of a single enrichment and sequencing platform with consistent information content is essential for analysis of samples screened at different times and it is therefore imperative for analytical integrity that all samples in the study are processed on the same sequencing platform, as each platform has a unique pattern of error Vishnuvajjala Hanumanth Rao Contracting ., SUITE 503L (No Street Address
2) BETHESDA, MD 20892 USA to this opportunity.
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