High Pressure Shot Cell Disruptor Equipment

General Information Document Type: Presolicitation Synopsis Number: 75N98026Q00736 Posted Date: July 2, 2026 Original Response Date: July 13, 2026 Current Response Date: July 13, 2026 Set Aside: N/A NAICS Code: 334516 Contracting (NIH), (OD) (OLAO) (OALM) Hospital and Laboratory Support Division 6701 Rockledge Drive Bethesda, MD 20817 INTRODUCTION THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The National Institutes of Health (NIH) intends to negotiate and award a contract without providing for full and open competition (Including brand-name) to: Constant Systems LTD 11 Low March Industrial Estate Low March, Daventry NN11 4SD GBR NORTH AMERICAN INDUSTRY SYSTEM (NAICS) CODE The intended procurement is classified under NAICS code 334516 with a Size Standard $1000. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2026-01, March 13, 2026. This acquisition is conducted under the procedures as prescribed in FAR subpart 13-Simplified Acquisition Procedures at an amount not exceeding the simplified acquisition threshold ($350,000). STATUTORY AUTHORITY This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures, Subpart 13.106-1 (b) (1), Soliciting from a single source and is not expected to exceed the simplified acquisition threshold. Contracts awarded using FAR Part 13-Simplified Acquisition Procedures are exempt from the

requirements of FAR Part 6-Competition

Requirements. GENERAL INFORMATION Title: High pressure Shot Cell Disruptor

Background Information: The National Institute of Diabetes and Digestive and Kidney Diseases conducts protein purification and characterization studies involving membrane proteins, including outer membrane proteins from Gram-negative bacteria. These studies require efficient cell disruption methods that preserve protein structure, membrane integrity, and sample quality for downstream structural and functional analyses. The institute also performs bacterial cell fractionation procedures that require isolation of intact outer membrane fractions for research applications. Conventional cell disruption methods, such as sonication and bead-beating, can introduce excessive shear forces, uneven energy transfer, and heat generation that may damage proteins and membrane structures. To support ongoing research activities, the National Institute of Diabetes and Digestive and Kidney Diseases requires a high-pressure homogenization system capable of providing controlled, reproducible cell disruption while maximizing sample recovery and minimizing processing-related damage. The One Shot Cell Disruptor utilizes controlled high-pressure homogenization to achieve efficient single-pass cell disruption with high sample recovery and reproducible performance. The instrument will support ongoing research activities and will be made available to multiple investigators requiring advanced cell disruption capabilities for protein purification, membrane biology, and related studies. CLOSING STATEMENT This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include a technical proposal, a cost-price proposal, the

period of performance, the Unique Entity ID (UEI), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by July 13, 2026 at 9:00 AM Eastern time and must reference solicitation number 75N98026Q00736. Responses may be submitted electronically to Mr. James Law,

Contracting Officer at [email protected]. Fax responses will not be accepted. "All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency.” LAW, JAMES B Contracting ., SUITE 503L (No Street Address